Consensus Cognitive Battery
For more details regarding the MATRICS Consensus Cognitive Battery,
The MATRICS Psychometric Study is based on Option 1 "Evaluating Recommended Cognitive Battery" from the initial MATRICS application. One of the key products of the MATRICS contract is an NIMH consensus cognitive battery that will be used for clinical trials of cognitive enhancing agents in schizophrenia. The MATRICS Neurocognition Committee is overseeing the process of selecting measures for the NIMH-MATRICS Cognitive Battery for Clinical Trials through a series of conference calls, a consensus meeting of relevant experts (held in April 2003), and a meeting using the RAND Panel method for evaluation of tests (to be held September 29th 2003). The RAND Panelists will evaluate tests within each of seven cognitive domains that were selected at the April consensus meeting: working memory, attention / vigilance, verbal memory and learning, visual memory and learning, speed of processing, reasoning and problem solving, and social cognition. After the RAND Panel makes its ratings, the MATRICS Neurocognition Committee will use these ratings to generate the initial "beta" version of the test battery. This version will be longer than the final battery because it will include one extra test for each of the cognitive domains to examine the psychometric properties of the most promising cognitive tests.
The MATRICS Psychometric Study will serve several functions and will be divided into two phases. The first phase will be to collect data on 150 patients with schizophrenia. In this phase, we will assess the test-retest reliability and relationship to functional status for each of the cognitive tests. Based on this information, the final selection of tests for the cognitive test battery will be made. This phase of the study will also examine and compare the psychometric properties of "proxy" measures of functional outcome and self-report measures of cognition. These measures will be selected based on suggestions from the MATRICS Outcomes Committee, and discussions with the NIMH Project Officer. In the second phase, we will administer the final test battery to a standardization sample of 300 people from the community (equal numbers of males and females for three age groups: 20-39, 40-49, and 50-59).
Phase 1: Psychometric study of schizophrenia patients with NIMH-MATRICS Cognitive Battery for Clinical Trials
Aim 1: To examine the short term test-retest reliability of tests within the beta version of the NIMH-MATRICS consensus battery
Aim 2: To examine the relationships between performance on tests within the beta version of the NIMH-MATRICS battery and functional status in the community
Aim 3: To use the information from Aims 1 and 2 to decide on the measures that will comprise the final NIMH-MATRICS battery
Aim 4: For candidates for "proxy measures" of functional outcome and subjective self-report measures of cognitive functioning, to examine test-retest reliability and relationships to cognitive performance and community functioning
Phase 2: Standardization sample of representative controls for the NIMH-MATRICS battery
Aim 5: To administer the NIMH-MATRICS battery to a representative sample of community controls stratified by age and sex to provide norms based on a common standardization sample
Phase 1: Study of schizophrenia patients with NIMH-MATRICS consensus batteryA total of 176 patients with a diagnosis of schizophrenia were assessed at baseline, 167 of the patients were retested at 4 weeks. The components of the assessment battery are listed below.
Phase 2: Standardization sample of representative controls for the cognitive battery
MATRICS Consensus Cognitive Battery for Clinical Trials, Beta VersionA total of 300 non-psychiatric individuals from the community will serve as a standardization sample for the consensus cognitive battery. Subjects will be recruited through the method of "random digit dialing" in which an outside company (Survey Sampling, Inc.) generates phone numbers within designated zip codes through a random process and then checks to ensure that the numbers belong to residences. To protect confidentiality, no names are provided. To obtain the desired sample size, we will initially recruit 83 potential subjects per site through this method. We expect that 14 of these subjects will not show for the assessments, and that an additional 9 will be excluded on screening. These projects leave 60 subjects for 5 sites, and an estimated total of 300 subjects. Each participant will receive a brief screening interview and the final consensus cognition battery on one occasion.
Phase 1: Study of schizophrenia patients with NIMH-MATRICS consensus batterySubjects were selected according to the following selection criteria:
Phase 2: Standardization sample of representative controls for the cognitive batterySubjects for this phase will be selected according to the following selection criteria:
Selection of SitesSites were selected that:
UCLA: Green and Nuechterlein
Publication PlanThe results of this psychometric study will be published as two separate papers in peer-review journals; one for each component of the study. The first paper will detail the test-retest reliability and the relationships to functional status of the beta version of the cognitive battery in the sample of 150 schizophrenic patients. The second paper will present the results of the final cognitive battery from the 300 subjects of the standardization sample.
Contact email@example.com for questions or comments about the MATRICS program and see our website - www.matricsinc.org - for details regarding the MATRICS Consensus Cognitive Battery (MCCB).
Contact firstname.lastname@example.org for questions or comments about with this web site.
|Revised: Sunday, 15-Jul-2007 21:46:29 PDT|